The Gut Microbiota as a Functional Modifier of Atherothrombosis (working title)

FB 09, Chemistry and Pharmacy; FB 04: University Medical Center, Center for Thrombosis and Hemostasis, Prof. Dr. rer. biol. hum. Christoph Reinhardt

Scientific career
Since 03/2022Doctoral candidate, Center for Thrombosis and Hemostasis, University Medical Center Mainz, Group of Prof. Dr. Christoph Reinhardt
10/2019–11/2021Master’s degree in Biomedicine, University Medical Center Mainz, master thesis in the group of Prof. Dr. Christoph Reinhardt
04/2016–12/2019Bachelor’s degree in Biology, Johannes Gutenberg University Mainz, bachelor thesis in the group of Prof. Dr. Eckhard Thines
Scientific activities
04/2020–09/2021Research Assistant, Institute for Microscopic Anatomy and Neurobiology, University Medical Center Mainz, group of Prof. Dr. Johannes Vogt, focus: electrophysiology, extracellular field recording in the hippocampus
03/2018–04/2020Research Assistant, Institute for Microscopic Anatomy and Neurobiology, University Medical Center Mainz, group of Prof. Dr. Johannes Vogt, focus: DNA analysis
04/2019–05/2019Internship, Institute of Virology, University Medical Center Mainz, group of Prof. Dr. Reinhild Prange
International experience
11/2022Visiting student, Human and Lung Research Institute, Cardiovascular Division, Cambridge, United Kingdom, group of Dr. Meritxell Nus
Publications
2024Khuu MP, Paeslack N, Dremova O, Benakis C, Kiouptsi K, Reinhardt C. The gut microbiota in thrombosis. Nat Rev Cardiol. 2024 Sep 17. PMID: 39289543.
2023Pontarollo G, Kollar B, Mann A, Khuu MP, Kiouptsi K, Bayer F, Brandão I, Zinina VV, Hahlbrock J, Malinarich F, Mimmler M, Bhushan S, Marini F, Ruf W, Belheouane M, Baines JF, Endres K, Reba SM, Raker VK, Deppermann C, Welsch C, Bosmann M, Soshnikova N, Chassaing B, Bergentall M, Sommer F, Bäckhed F, Reinhardt C. Commensal bacteria weaken the intestinal barrier by suppressing epithelial neuropilin-1 and Hedgehog signaling. Nat Metab. 2023 Jul;5(7):1174-1187. PMID: 37414930.

Dremova O, Mimmler M, Paeslack N, Khuu MP, Gao Z, Bosmann M, Garo LP, Schön N, Mechler A, Beneich Y, Rebling V, Mann A, Pontarollo G, Kiouptsi K, Reinhardt C. Sterility testing of germ-free mouse colonies. Front Immunol. 2023 Nov 7;14:1275109. PMID: 38022683.
2022Paeslack N, Mimmler M, Becker S, Gao Z, Khuu MP, Mann A, Malinarich F, Regen T, Reinhardt C. Microbiota-derived tryptophan metabolites in vascular inflammation and cardiovascular disease. Amino Acids. 2022 Apr 22. PMID: 35451695.
2021Bayer F, Dremova O, Khuu MP, Mammadova K, Pontarollo G, Kiouptsi K, Soshnikova N, May-Simera HL, Endres K, Reinhardt C. The Interplay between Nutrition, Innate Immunity, and the Commensal Microbiota in Adaptive Intestinal Morphogenesis. Nutrients. 2021 Jun 26;13(7):2198. PMID: 34206809.
Conference Attendance
2024ISTH 2024 Congress. Khuu MP, Dremova O, Miedema J, Bochenek M, Todorov H, Gerber S, Schäfer K, Reinhardt C. Gut microbiota and diet as organotypic regulator of the microvascular endothelial transcriptome. 22 – 26 June 2024 in Bangkok. (Poster)

GTH 2024. Dremova O, Khuu MP, Rupprecht H, Sarpong B, Bury L, Boujataoui S, Sommer F, Marini F, Reinhardt C. Diet and gut microbiota orchestrate the hepatic endothelial transcriptome in atherosclerosis. 27 February – 01 March in Vienna. (Poster)
2023GTH 2023. Khuu MP, Kiouptsi K, Pontarollo G, van der Vorst EPC, Döring Y, Müller M, Schäfer K, Reinhardt. Gut microbiota promotes arterial thrombus formation in hyperlipidemic Ldlr-/-mouse model. 21 – 24. February 2023 in Frankfurt. (Oral talk)

#Resilience2023 – 8th International Symposium on Resilience Research. 28 – 30 September 2023 in Mainz.
2022ISTH 2022 Congress. 22 – 26 June 2022 in London.
Awards and academic engagements
05/2025Young-DZHK Travel Grant
Since 04/2025Junior fellow of the Gutenberg Academy Fellows Program (GAFP)
Since 02/2024Young-DZHK Member of the Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK)
Since 03/2022Mainz Research School of Translational Biomedicine (TransMed)